张薇

张薇

副教授 东南大学医学院

电子邮箱：zhang.wei@seu.edu.cn

通讯地址：南京市鼓楼区丁家桥87号东南大学医学院

张薇，1988年出生，东南大学医学院副教授，硕士生导师。近10年来专注于组织工程与再生医学领域，通过生物医学、材料科学与临床医学多学科交叉，应用干细胞、生物材料（蚕丝/胶原）与生长信息（物理刺激/生物小分子等）针对包括软骨、皮肤、角膜等富含胶原组织的修复再生。

迄今已在本领域国际主流学术期刊上发表SCI文章30余篇，总计影响因子>200 分。作为第一作者和通讯作者发表文章17篇，总影响因子 >100 分，其中4篇 IF>10，平均 IF~7，代表性论文发表在Biomaterials（IF=10.317, 生物材料领域排名1/38)，Chemical Engineering Journal (IF=10.652, 化学工程排名4/143)，Bioactive Materials（IF=8.724, 生物材料领域排名2/38）等本领域高水平期刊。1篇论文入选Biology & Biochemistry领域ESI前1%高被引论文，单篇最高被引200余次，共计被引1000余次，H指数17。作为第一发明人授权发明专利2项。参与3本本领域书籍章节写作（均由人民卫生出版社出版发行）。目前作为项目负责人主持国家自然科学基金、江苏省自然科学基金等多个项目。作为主要完成人获浙江省自然科学奖一等奖（排名第4）。

张薇博士在相关领域的开创性研究获得国际同行的广泛认可，2篇文章被选为Advanced Healthcare Materials期刊的正封面文章 (Front cover), 并获得Advanced Science News, ChemistryViews.org等专业领域网站Highlight。受邀担任美国化学学会ACS Biomaterials Science & Engineering (IF=4.152)生物材料期刊青年编委，中国科技期刊卓越行动计划Military Medical Research (IF=2.325)青年编委，Frontiers系列期刊Handling Editor，及Stem Cells International（IF=3.869) 首席客座编辑（Lead Guest Editor)。同时担任Advanced Functional Materials, Chemical Science, Acta Biomaterialia等重要英文期刊评审专家。近年来，张薇博士多次获奖并应邀在重要国际学术会议上作专题学术报告，如第15届新加坡国际生物医学工程大会YIA青年研究者奖（七位中唯一一位来自中国）等。

学习工作经历

10/2018 –至今

副教授，东南大学医学院，生理学系

8/2015 – 8/2018

博士后，瑞典Ume University整合医学生物学系 (IMB)

导师：Patrik Danielson教授

9/2010 – 6/2015

博士（推免，直接攻博），浙江大学医学院，干细胞和再生医学专业

导师：欧阳宏伟教授

2/2014 – 6/2014

访问****，澳洲University of Western Australia，病理与检验医学学院

导师：Jiake Xu教授

9/2006 – 6/2010

学士，南京师范大学生命科学学院，生物科学（国家理科基地）专业

荣誉奖励

2020年：浙江省自然科学奖一等奖“运动系统软组织疾病的病理机制和再生研究”（排名第4）

2020年：东南大学“至善青年****”A类

2020年：中国科技期刊卓越行动计划Military Medical Research (IF=2.325)青年编委

2020年：Stem Cells International 首席客座编辑 (IF=3.869)

2018年：美国化学学会ACS Biomaterials Science & Engineering (IF=4.152)青年编委

2017年：Stem Cells International 首席客座编辑 (IF=3.869)

2015年：浙江省优秀毕业生, 浙江省教育厅

2014年：澳洲政府奋斗奖学金Endeavour Scholarships and Fellowships，澳大利亚教育部

2014年：研究生国家奖学金，中华人民共和国教育部

2013年：第十五届新加坡国际生物医学工程大会青年研究者奖（YIA，七位中唯一一位来自中国）

2013年：研究生国家奖学金，中华人民共和国教育部

2013年：第六届全国组织工程与再生医学大会 Poster二等奖（TOP 3）

2012年：博士研究生学术新人奖，中华人民共和国教育部

2012年：研究生国家奖学金，中华人民共和国教育部

学术成果

基金：

东南大学“至善青年****”支持计划A类，2021.1-2023.12，负责人

国家自然科学基金青年基金项目，2020.1-2022.12，负责人

江苏省自然科学基金青年基金项目，2019.7-2022.6，负责人

南京市留学人员科技创新项目择优资助，2020.1-2022.12，负责人

（省优势）新进教师人才引进启动费，2019，负责人

东南大学基础科研扶持项目，2019.4-2019.12，负责人

东南大学中央高校建设一流大学（学科）和特色发展引导专项资金经费，2019

已发表SCI文章：

Zhang L#, Zhang W#, Hu YJ, Fei Y, Liu HY, Huang ZZ, Wang CL, Ruan DF, Heng BC, Chen WS, Shen WL*. Systematic review of silk scaffolds inmusculoskeletal tissue engineering applications in the recent decade. ACS Biomater Sci Eng. 2021.(共同一作；IF=4.152)

Zhang W*, Chen JL, Qu ML, Backman J, Zhang AN, Liu HY, Zhang XP, Zhou QJ*, Danielson P*. Sustained release of TPCA-1 from silk fibroin hydrogels preserves keratocyte phenotype and promotes corneal regeneration by inhibiting interleukin-1β signaling. Adv Healthc Mater. 2020, 9(17), **. (IF=7.367)

Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL, Sheng RW, Yao QQ*, Chen JL*. An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration. Bioactive Materials. 2020, 5:832-843. (IF=8.724)

Zhang W*, Ling C, Liu HY, Zhang AN, Mao L, Wang J, Chao J, Backman L, Yao QQ*, Chen JL*. Tannic Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell Behavior and Osteochondral Regeneration. Chem Eng J. 2020, 396:125232. (IF=10.652)

Zhang W*, Ling C, Li XL, Sheng RW, Liu, Liu HY, Zhang AN, Jiang YJ, Chen JL*, Yao QQ*. Cell-free biomimetic scaffold with cartilage extracellular matrix-like architectures for in situ inductive regeneration of osteochondral defects. ACS Biomater Sci Eng. 2020, 6(12),6917–6925.(IF=4.152)

Sheng RW, Jiang YJ, Backman LJ, Zhang W*, Chen JL*. The application of mechanical stimulations in tendon tissue engineering. Stem Cells Int 2020, 2020: **. (IF=3.869，共同通讯，一作为大二本科生)

Zhang W, Robertson W, Zhao JM, Chen WW, Xu JK. Emerging trend in the pharmacotherapy of osteoarthritis. Front Endocrinol. 2019, 10:431. (IF=3.644)

Zhang W, Li Y, Jiang DM, Xie SJ, Zeng MF, Chen JL, Chen LK, Ouyang HW, Zou XH. Promotion of Hernia Repair with High-Strength, Flexible, and Bioresorbable Silk Fibroin Mesh in a Large Abdominal Hernia Model. ACS Biomater Sci Eng 2018, 4, 2067?2080. (IF=4.152)

Chen JL#, Zhang W#, Backman J, Kelk P, Danielson P. Mechanical stresspotentiates the differentiation of periodontal ligament stem cells intokeratocytes. Brit J Ophthalmol 2018, 102:562–569. (共同一作；IF=3.611)

Zhang W, Chen LK, Chen JL, Wang LS, Gui XX, Ran JS, Xu GW,Zhao HS, Zeng MF, Ji JF, Qian L, Zhou JD, Ouyang HW, Zou XH. Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial. Adv Healthc Mater 2017, 6(10), **. (IF=7.367, 正封面文章, highlighted by Advanced Science News, and ChemistryViews.org)

Zhang W,Chen JL, Backman J, Malm A, Danielson P. Surface Topography andMechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model. Adv Healthc Mater 2017, 6(5), **. (IF=7.367, 正封面文章；highlighted by Advanced Science News)

Chen JL#, Zhang W#, Kelk P, Backman J, Danielson P. Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered 3D model. Stem Cell Res Ther. 2017,8:260. (共同一作；IF=5.116)

Zhang W, Ouyang HW, Dass CR, Xu JK. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Research 2016, 4: 15040. (IF=11.508, ESI前1%高被引论文)

Zhang W, Heng BC, Jiang YZ, Ouyang HW. Clinical Translation of Autologous Cell-Based Tissue Engineering Techniques as Class Three Therapeutics in China- Taking Cartilage Tissue Engineering as an Example. Journal of Orthopaedic Translation 2014,2(2): 56-65. (IF=3.986)

Zhang W, Chen JL, Tao JD, Jiang YZ, Hu CC, Huang L,Ji JF, Ouyang HW. The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive topartial-thickness cartilage defects repair. Biomaterials 2013, 34(3):713-723. (IF=10.317)

Zhang W, Chen JL, Tao JD, Hu CC, Chen LK, Zhao HS, Xu GW, Heng BC, Ouyang HW. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of abi-layer collagen-silk scaffold. Biomaterials 2013, 34(25):6046-6057. (IF=10.317)

Zhang W, Chen JL, Zhang SF, Ouyang HW. Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair. Arthritis Res Ther 2012,14(4):221. (IF=4.103)

Chen JL, Zhang W, Liu ZY, Heng BC,Ouyang HW, Dai XS. Physical regulation of stem cells differentiation intoteno-lineage: current strategies and future direction. Cell Tissue Res 2014, 360(2):195-207. (IF=4.044）

Chen JL, Zhang W, Liu ZY, Zhu T, Ouyang HW. Characterization and comparison of post-natal rat Achilles tendon-derivedstem cells at different development stages. SciRep 2016, 6: 22946. (IF=3.998)

Chen JL, Zhang EC, Zhang W, Liu ZY, LuP, Zhu T, Yin Z, Backman LJ, Liu HH, Chen X, Ouyang HW. Fos promotes earlystage teno-lineage differentiation of TSPCs in tendon. Stem Cells Transl Med 2017,6(11):2009–2019. (IF=6.429)

Jiang Y, Cai Y, Zhang W, Yin Z, Tuan RS, Ouyang HW. Human Cartilage-Derived Progenitor Cells from Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem Cells Transl Med 2016,5(6):733-44 (IF=6.429)

Zhang SF, Jiang YZ, Zhang W, Chen LK,Tong T, Liu WL, Mu Q, Liu H, Ji JF, Ouyang HW, Zou XH. Neonatal Desensitization Supports Long-Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression. Stem Cells Dev 2013,22(1): 90-101. (IF=3.082)

Jiang YZ, Chen LK, Zhang SF, Tong T, Zhang W, Liu WL, Xu GW, Tuan RS, Heng BC, Crawford R, Xiao Y, Ouyang HW. Incorporation of bioactive polyvinylpyrrolidone iodine within bilayered collagen 1 scaffolds enhances the differentiation and subchondral osteogenesis of MSCs. Acta Biomater 2013,9(9):8089-98. (IF=7.242)

Chen JL, Lan J, Liu DL, Backman L, Zhang W, Zhou QJ, Danielson P. Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea. Stem Cells Transl Med 2017,6(5):1356-1365. (IF=6.429)

Shen WL, Chen JL, Zhu T, Chen LK, Zhang W, Fang Z, Heng BC, Yin Z, Chen X, Ji J, Chen W, Ouyang HW. Intra-Articular Injection of Human Meniscus Stem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing. Stem Cells Transl Med 2014, 3(3):387-94. (IF=6.429)

Cai DD, Zhou FF, Zhang XZ, Mu Q, Li J, Zhang W, Zhu SA, Jiang YZ, Shen WL, Zhang SF, Ouyang HW. Silk-CS scaffold with immuno-inhibition property for joint cartilage repair. Acta Biomater 2017, 63:64-75. (IF=7.242)

Zhang SF, Chen LK, Jiang YZ, Cai YZ, Xu GW, Tong T, Zhang W, Wang LL, Ji JF, Shi PH, Ouyang HW. Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration. Acta Biomater 2013,9(7):7236-47. (IF=7.242)

Shen W, Chen X, Hu Y, Yin Z, Zhu T, Hu J, Chen J, Zheng Z, Zhang W, Ran J, Heng BC, Ji J, Chen W, Ouyang HW. Long-term effects of knitted silk-collagen sponge scaffold on anterior cruciate ligament reconstruction and osteoarthritis prevention. Biomaterials. 2014, 35(28):8154-63. (IF=10.317)

发明专利：

张薇，陈隆坤，谢淑君。一种胶原基质软骨修复膜、制备方法及应用。专利号：ZL 2014 1 **.X

张薇，陈隆坤，徐国伟，宣铁锋。含生物活性因子的组织工程软骨支架及其制备方法与应用。专利号：ZL 2015 1 **.1

书籍章节：

生物材料与组织再生。出版中，人民卫生出版社

创伤、烧伤与再生医学。2014，人民卫生出版社

再生医学 ：基础与临床。2013，人民卫生出版社