陈峻青

陈峻青 副教授

研究方向：生物催化，生物制药

荣誉奖励：

1.2015年江苏省“六大人才高峰”第十二批高层次人才选拔培养资助（生物技术和新医药产业）

2.2015年度宿迁市“创业创新领军人才集聚计划”（创新人才）

3.2014江苏省科学技术奖，二等奖（排名第二）

4.2013江苏省百件优质发明专利，一种酮还原酶基因及其应用 排名第一

发表论文:

1.JunqingChen, MinSun, JinCai, MengCao, WenZhou, MinJi. The Synthesis and CrystalStructure of (4a,8b,13b,16b)-13-Methyl-16,18-diol-17-Norkaurane: A SimultaneousReduction Product of Isosteviol. J Chem Crystallogr. 2011, 41:519–522

2.JunqingChen, Xiaoming Zha, MinSun, JinCai, WenZhou, MinJi. Synthesis and In VivoAcute Antihyperglycemic Evaluation of Novel Isosteviol Derivatives. Letters inDrug Design & Discovery. 2010, 7, 686-693

3.Zhou GX; Li LS; Xing J; Cai J;Chen JQ; Liu PD; Gu N ; Ji M.Layer-by-layer construction of lipid bilayer on mesoporous silica nanoparticleto improve its water suspensibility and hemocompatibility. Journal of sol-gelscience and technology. 2017, 82(2):490-499

4.Zhilong Zhang, Gaoxin Zhou,Bo Chen, Jin Cai,Junqing Chen.Xuan Wu, Wenxiou Qi, Min Ji. Novel yolk–shell structured silicananosphere with a movable silica-coated gold core. Journal of Sol-Gel Scienceand Technology. 2016, 77(2): 516-520

5.Zhou GX; Li LS; Xing J; Jalde S; Li Y; CaiJ;Chen JQ; Liu PD; Gu N; Ji M. Redox responsive liposomal nanohybrid cerasomes for intracellular drug delivery. Colloidsand Surfaces B-Biointerfaces. 2016,148: 518-525

6. Liu HD; Chen B; Cai J;Chen JQ; Ji M. The trifluoromethylationof iminium salts by the addition of trifluoromethyltrimethylsilane. Journal ofChemical Research. 2016, 6: 379-381

7.Xi Zong, Jin Cai,Junqing Chen, Peng Wang,Gaoxin Zhou,Bo Chen,Wei Li,Min Ji. Design and synthesis of imidazole N–Hsubstituted amide prodrugs as inhibitors of hepatitis C virus replication. Bioorganic& Medicinal Chemistry Letters. 2015, 25(16): 3147-3150

8. Liu HD; Lv YF ; Li Y; Cai J;Chen JQ; Qin, Y; Ji, M. A novel andefficient synthesis of anti-cancer agent, mereletinib. Journal of ChemicalResearch. 2015, 39(6): 318-320

9.Cai J; Wei HT; Hong KH; Wu XQ; Zong X; CaoM; Wang P; Li LS; Sun CL; Chen B; Zhou GX;ChenJQ; Ji M. Discovery, bioactivity and docking simulation of Vorinostatanalogues containing 1,2,4-oxadiazole moiety as potent histone deacetylaseinhibitors and antitumor agents. Bioorganic & Medicinal Chemistry. 2015,23(13): 3457-3471

10.Wang P; Cai J;Chen JQ; Ji, M. Agarose-Alumina Composite Supported PalladiumCatalyst for Suzuki Coupling Reactions. Journal of The Brazilian ChemicalSociety. 2015, 26(4): 748-754

11.Chunlong Sun, Yang Wu,Peng Wang, Gaoxin Zhou, Xi Zong, Bo Chen, Jin Cai,Junqing Chen, Min Ji. A novelnear-infrared fluorescent probe was synthesized and its application in imagingof living cells. Journal of Sol-Gel Science and Technology. 2014, 71(2):211–216

12.Peng Wang,Jin Cai,Junqing Chen,MinJi. A novel near-infraredfluorescent probe was synthesized and its application in imaging of livingcells. European Journal of Medicinal Chemistry. 2015, 93: 1-8

13.Chunlong Sun, Jin Cai,Junqing Chen, Yang Wu,Peng Wang, Gaoxin Zhou, Xi Zong, Bo Chen, Yongfeng Lv,Min Ji. The Synthesis of a Novel Near-Infrared Fluorescent Probe and itsApplication in Imaging of Living Cells. Applied Biochemistry and Biotechnology.2015, 175(3): 1644–1650

已授权专利:

1.陈峻青，石利平，尹晓龙，王清 一种酮还原酶基因及其应用，CN104928265B

2.陈峻青，李黎，吉民，戚文秀 一种链格孢菌Y1309‑1及其应用，CN104480025B

3.陈峻青，吉民，戚文秀 一种链格孢菌Y1309-1在制备纳米金方面的应用，CN104551001B

4.石利平，蔡进，陈峻青，吉民，龚仕荣，万新强，徐春涛 一种索非布韦中间体及其制备方法，CN105348320B

5.吉民，胡兵，蔡进，曹萌，张入仁，王鹏，常维维，陈峻青，宗玺Hedgehog信号通路抑制剂，CN103992311B

6.蔡进，吉民，曹萌，陈峻青基于MIM蛋白环肽抑制剂的靶向长循环脂质体及其制备方法与应用，CN103845737B

7.陈峻青，石利平，尹晓龙，王清 一种酮还原酶基因及其应用，CN102827851B

8.陈峻青，蔡进，吉民，尹晓龙，漆志文，石利平，徐春涛 一种卤醇脱卤酶基因突变体及其应用，CN102827853B

9.吉民，陈峻青，余佳，周文 异甜菊醇衍生物及其应用，CN101445457B

科研项目:

1.国家自然科学基金面上项目，61178057，用于生物标记及荧光成像dendrimer分子的多光子上转换荧光发射及荧光共振能量传递、2012/1/1-2015/12/30，60万元，已结题，参与。

2.国家自然科学基金面上项目，30472011，多巴胺D3受体配体用于治疗帕金森综合症等中枢疾病、2005/1/1- 2007/12/31，21万元，已结题，参与。

3.参与或主持江苏省产学研前瞻项目、江苏省支撑计划(社会发展)、江苏省重大成果转化项目、江苏省基础研究计划项目及多项企业合作项目。