谢春明

谢春明

教授 东南大学附属中大医院神经内科

研究方向

1、老年痴呆的早期识别与防治

2、抑郁症的基础与临床研究

3、脑血管病的基础与临床研究

4、神经认知与神经功能影像

荣誉奖励

1、江苏省预防医学科技奖，一等奖，2021，排名第一

2、华夏医学科技奖，二等奖，2019，排名第二

3、江苏省卫生厅新技术引进奖，一等奖，2019，排名第一

4、江苏省双创团队，2018

5、中国神经内科杰出青年医师，2017

6、入选江苏省“333高层次人才工程”培养对象，2016

7、江苏省“六大人才高峰”高层次人才（2014）

8、教育部高等学校科学研究优秀成果奖自然科学奖，一等奖，2016

9、江苏省卫生厅新技术引进奖一等奖（排名第一，2015）

10、江苏省科技进步奖一等奖（排名第七，2014）

11、南京市科技进步奖二等奖（排名第二,2014）

第一作者论文（近5年来发表的主要论著目录,*表示通讯作者）

1)Zang Feifei, Zhu Yao, Zhang Qianqian, Tan Chang,Wang Qing, Xie Chunming*, on behalf of Alzheimer’s Disease Neuroimaging Initiative. APOEgenotype moderates the relationship between LRP1 polymorphism and cognitionacross the Alzheimer's disease spectrum via disturbing default mode network. CNS Neuroscience & Therapeutics, 2021

2)Zang Feifei, Zhu Yao, Liu Xinyi, Fan dandan, WangQing, Zhang Qianqian, He Cancan, Zhang Zhijun, Xie Chunming*, for the Alzheimer’s Disease NeuroimagingInitiative3, for the Alzheimer’s Disease Metabolomics Consortium. Polygeniceffects of lipid metabolic pathway accelerated pathological changes anddisrupted default mode network trajectory across the Alzheimer’s diseasespectrum. Journal of Clinical Psychiatry.2021

3)Zhu Y, Zang F, Wang Q, Zhang Q, Tan C, Zhang S, HuT, Qi L, Xu S, Ren Q, Xie C*. Connectome-based model predicts episodic memory performance inindividuals with subjective cognitive decline and amnestic mild cognitiveimpairment. Behav Brain Res. 2021 Aug 6; 411:113387.

4) Liu XY, HeCC, Fan DD, Zang FF, Zhu Y, Zhang HS, Zhang Z, Zhang HX, Xie C. Alterations ofcore structural network connectome associated with suicidal ideation in majordepressive disorder patients. Translational Psychiatry. Accepted

5)Hui Wang; Liang Xu; Chuying Lai; Kaiyu Hou;Junliang Chen; Yaowei Guo; Abhijeet Sambangi; Shreya Swaminathan; Chunming Xie;Zheng Wu; Gong Chen. Region-specific distribution of Olig2-expressingastrocytes in adult mouse brain and spinal cord. Molecular Brain. Accepted.

6)Zhang QQ, Wang Q, HeCC, Zhu Y, Zang FF, Tan C, Zhang SK, Zhang ZJ, Xie CM. Altered RegionalCerebral Blood Flow and Brain Function Across Alzheimer's Disease Spectrum: A Potential Biomarker. Frontiers in Aging Neuroscience, 2021

7)Wang Q, He C, Wang Z, Zhang Z, Xie C. Dynamic connectivity alteration facilitates cognitive decline inAlzheimer's disease spectrum.BrainConnect. 2020 (online).

8)Cancan He, Ying Bai, Zan Wang, Dandan Fan, Qing Wang,Xinyi Liu, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Honghong Yao, ChunmingXie. Identification of MicroRNA-9 Linking the Effects of Childhood Maltreatmenton Depression Using Amygdala Connectivity. NeuroImage,2021, 224:117428.

9)Fang-yuan Qian; Yu-Dong Guo; Juan Zu; Jin-HuaZhang; YiMing Zheng; Abdoulaye Idriss Ali; Zhao-hui Pan; Chun-ming Xie;Han-chao Gao; Zhi-Jun Zhang. A novel recessive mutation affecting DNAJB6acauses myofibrillar myopathy. ActaNeuropathologica Communications, 2021, 9(1):23.

10)Xinyi Liu, Cancan He, Dandan Fan, Yao Zhu, FeifeiZang, Qing Wang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang, Chunming Xie. Disrupted rich-clubnetwork organization and individualized identification of patients with majordepressive disorder. Progress inNeuropsychopharmacology & Biological Psychiatry. 2020:110074.

11)Qianqian Zhang, Chunming Xie. APOE4 Drives EarlyBlood-Brain Barrier Damage in Alzheimer's Disease. Neuroscience Bulletin. 2020, Accepted.

12)Wang Qing, He Cancan, Zhu Yao, Zhang Qianqian, ZhangZhijun, XieChunming*, on behalf of Alzheimer’sdisease Neuroimaging InitiativeCortical Atrophy Mediates the Accumulating Effectsof Vascular Risk Factors on Cognitive Decline in the Alzheimer’s diseaseSpectrum. Aging, 2020,29;12(14):15058-15076.

13)Yao Zhu, Feifei Zang, Xinyi Liu, Dandan Fan,Qianqian Zhang, Qingguo Ren*, Chunming Xie*, on behalf of Alzheimer’s DiseaseNeuroimaging Initiative. Endocytosis-pathway Polygenic Scores Affects theHippocampal Network Connectivity and Individualized Identification across theHigh-risk of Alzheimer’s Disease. Brain Imaging Behav. 2020 (Accepted)

14)Zhang Z, Zhang H, Xie CM, Zhang M, Shi Y, Song R, Lu X, Zhang H, Li K, Wang B, YangY, Li X, Zhu J, Zhao Y, Yuan TF, Northoff G. Task-related functional magnetic resonance imaging-based neuronavigation forthe treatment of depression by individualized repetitive transcranial magneticstimulation of the visual cortex.Sci ChinaLife Sci, 2020 (online)

15)Gao-Jia Zhang, Shaoke Zhang, Zan Wang, Yi-XinZhu, Jun Kong, Li-Li Huang, Yi-Jing Guo, Yan-Juan Wang, Rong-Cheng Zou,Chunming Xie*. Fatal and Rapid Progressive Isolated Cerebral MucormycosisInvolving the Bilateral Basal Ganglia: A Case Report. Frontiers in Neurology-Neuroinfectious Diseases. 2020 online

16)QianFY, Li ZL, Guo YD, Gao HC, Gu LH, Le K, Xie CM, Wang B, Zhang ZJ. Hypoxia-induciblefactor-prolyl hydroxylase inhibitor ameliorates myopathy in a mouse model ofchronic kidney disease.Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1265-F1273.

17)ZhuY, Gong L, He C, Wang Q, Ren Q, Xie C; Alzheimer’s Disease NeuroimagingInitiative. Default Mode Network ConnectivityModerates the Relationship Between the APOE Genotype and Cognition andIndividualizes Identification Across the Alzheimer's Disease Spectrum.J Alzheimers Dis. 2019;70(3):843-860.

18)ZhangY, Du LF, Bai Y, Han B, He CC, Gong L, Huang RR, Shen L, Chao J, LiuP, Zhang HX, Zhang HS, Gu L, Li JX, Hu G, Xie CM, Zhang ZJ, Yao HH. CircDYM ameliorates depressive-like behavior by targetingmiR-9 to regulate microglial activation via HSP90 ubiquitination, Molecular Psychiatry, 2020, 25(6):1175-1190 (IF=11.973)

19)He CC, Gong L, Yin YY, Ye Q, Bai F, Yuan YG, Zhang HS, Lv LX,Zhang HX*, Xie C*, Zhang ZJ. Amygdala Connectivity Mediates theAssociation between Anxiety and Depression in Major Depressive DisorderPatients. Brain Imaging Behav. 2019Aug;13(4):1146-1159.(IF=3.659)

20)GongL, He C, Zhang H, Zhang H, Zhang Z, Xie C. Disruptedreward and cognitive control networks contribute to anhedonia in depression. J Psychiatr Res. 2018;103:61-68.

21)Gong L, He CC, Yin YY, Wang Hui, YeQ, Bai F, Yuan YG, Zhang HS, Lv LX, Zhang HX, Xie C*, Zhang ZJ. Mediating role of reward network in therelationship between the dopamine multilocus genetic profile anddepression. Frontiers inMolecular Neuroscience. 2017; 10:292 (IF=5.076)

22)Gong L, Shu H, He CC, Ye Q, BaiFeng, Xie C*, Zhang Z*. Convergentand divergent effects of apolipoprotein Eε4 andε2 alleles on amygdalafunctional networks in non-demented old adults. Neurobiology of Aging. 2017;54:31-39(IF=5.163).

23)Gong L, He C, Yin Y, Ye Q, Bai F, Yuan Y, Zhang H, Lv L, Zhang H, Zhang Z, Xie C*. Nonlinearmodulation of interacting between COMT and depression on brain function. Eur Psychiatry. 2017 Jun 9;45:6-13.(IF=3.123)

24)Gong L, Hou Z, Wang Z, He C, Yin Y, Yuan Y, Zhang H, Lv L, Zhang H, Xie C*, Zhang ZJ. Disrupted topology of hippocampalconnectivity is associated with short-term antidepressant response in majordepressive disorder. J Affect Disord. 2017 Aug31;225:539-544 (IF=3.432)

25)Gong L, YinYY, He CC, Ye Q, Bai F, Yuan YG, Zhang HS, Lv LX, Zhang HX*, Xie C*, Zhang ZJ. Disrupted rewardcircuits is associated with cognitive deficits and depression severity in majordepressive disorder. J Psychiatric Res.2017;84:9-17 (IF=4.465).