制备直径约为10nm的γ- Fe2O3磁性纳米材料（MNPs），并用生物相容性小分子DMSA、APTS和GLU进行修饰，从而获得尺寸、磁学性能等相同而表面性质不同的三种纳米材料。考察它们对SD大鼠主动脉平滑肌细胞的作用和影响。结果表明磁性纳米颗粒对平滑肌细胞最主要的影响是细胞的增殖，影响程度依赖于颗粒的浓度，培养时间和颗粒表面的性质。其中对细胞形貌、炎症反应等则没有明显的影响。
Fig. 4 pH-dependent zeta potential curves of DMSA-MNPs, APTSMNPs, and GLU-MNPs
Fig. 7 The thin-section TEM images of SMC incubated with 0.1 mg/mL of DMSA-MNPs for 24 h. a Control SMC 9 10 K, b SMC incubated with DMSAMNPs 9 10 K, and c SMC incubated with DMSAMNPs 9 35 K. Arrows denote the MNPs or their aggregates
Song Zhang, Xiangjian Chen, Chunrong Gu, Yu Zhang, Jindan Xu, Zhiping Bian, Di Yang, Ning Gu.The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells, Nanoscale Res Lett (2009) 4:70–77
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