肝血流灌注信息对临床诊断肝疾病有着重要的意义。图像分析系统可以帮助医生进行有效准确的诊断。本研究的目的是提出一种基于超声造影成像（contrast-enhanced ultrasound imaging ,CEUI）的定量分析肝血流灌注的图像分析方法。该方法包括图像帧的选择，图像配准，数字减影和灰阶计算。然后，通过处理一个图像序列得到肝血流灌注的时间强度曲线（time-intensity curve ，TIC）。该方法的核心是数字减影，并通过图像帧的选择和图像配准来提高其准确性。该方法的优点是可以直接得到整个肝的血流灌注信息，而传统的分析方法很难得到，因此该方法可以作为传统分析方法的一个有效的补充。利用该方法定量评价了一只家兔的肝血流灌注，结果表明了该方法的有效性。
An image analysis method for quantification of hepatic perfusion based on contrast-enhanced ultrasound imaging
Information about hepatic perfusion is used in clinical liver disease diagnosis. An image analysis system can help physicians make efficient and accurate diagnosis. The objective of this study is to propose an image analysis method for the quantification of the hepatic perfusion based on contrast-enhanced ultrasound imaging (CEUI). The proposed method contains frame selection, image registration, digital subtraction and grey-scale calculation. Then, by processing an image sequence, a time-intensity curve (TIC) for hepatic perfusion is derived. The kernel of this image analysis technology is digital subtraction and its accuracy is improved by frame selection and image registration. The advantage of this method is that it can obtain the perfusion information of the whole liver which is rarely obtained by traditional image analysis technology; therefore, it is a supplement of the traditional image analysis method. This method is applied on the quantification of a rabbit’s hepatic perfusion and the result shows the efficiency of it.
Yi-xin Li, Fang Yang & Ning Gu*.An image analysis method for quantification of hepatic perfusion based on contrast-enhanced ultrasound imaging.J. Biomedical Science and Engineering,2008, 1, 116-120
研究进展