本研究组与中大医院普外科合作，设计并合成了一种新型的聚乳酸(PLLA)修饰的聚丙烯补片(PP-g-PLLA)，并用于Sprague–Dawley (SD)大鼠腹壁缺损修复研究。首先应用氧等离子体将聚丙烯(PP)表面进行氧化处理获得表面羟基化的聚丙烯（PP-OH），然后将聚乳酸（PLLA）接枝在聚丙烯的表面，从而获得聚乳酸（PLLA）接枝的聚丙烯（PP-g-PLLA）补片材料，并进行了SD大鼠腹壁缺损修复实验。将36只SD大鼠随机分成6组，每组6只，控制组为未修饰的聚丙烯补片（PP）组，计32只，实验组为PLLA接枝的聚丙烯补片（PP-g-PLLA），计32只。分别观察术后一周，两周和一个月后的粘连和炎症情况。通过与控制组相比较，发现PP-g-PLLA补片显示了较好的抗腹腔粘连特性，粘连等级为一级（粘连面积小于25%）(P < 0.05)，但术中所引起的炎症形成和控制组相比并没有显著差异 (p> 0.05)。这需要对嫁接工艺进一步进行改进，以获得更好的接枝结构和优异的力学性能。
Zhigang Zhang,Tianzhu Zhang,Junsheng Li,Zhenling Ji,Hemei Zhou,Xuefeng Zhou,Ning Gu. Preparation of poly(L-lactic acid)-modified polypropylene mesh and its antiadhesion in experimental abdominal wall defect repair. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH B: APPLIED BIOMATERIALS, 2013, DOI:10.1002/jbm.b.32947
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.32947/pdf
SCHEME 1. Schematic illustration of grafting poly(L-lactic acid) (PLLA) on hydroxyl-terminated polypropylene (PP-OH) surface
FIGURE 2. (A1, A2) Aspect of the PP mesh surface observed through SEM. (B1, B2) Aspect of the PP mesh (PP-OH) surface (oxidized with oxygen plasma for 30 s) observed through SEM. (C1, C2) Aspect of the PP-g-PLLA mesh surface observed through SEM.
FIGURE 3. (A) Seven days after defect repair procedure with PP-g-PLLA mesh. The visceral surface of the mesh was smooth and without any adhesion formation. Adhesion score was 0. (B) Fourteen days after defect repair procedure with PP-g-PLLA mesh. There were a few slender fibrous and omental adhesions, and most were formed at the edges of the mesh. The rest of the mesh visceral surface was smooth. Adhesion score was 1. (C) Thirty days after defect repair procedure with PP-g-PLLA mesh. The degrees of adhesion were the same as (B). Adhesion score was 1. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.].
