本文构建了一种以数个单分散四氧化三铁纳米立方晶体形成的组装体为核、双油酸-聚乙二醇两亲性聚合物为壳的核-壳式“魔方”形载体，在魔方的内、外表面装载紫杉醇，同时兼具高载药量、高磁响应性、速释、缓释等特性。体内外结果显示，与市售紫杉醇注射液相比，该载体可提高肿瘤细胞对药物的摄取、延长血液循环时间、增加肿瘤细胞的凋亡，并可通过核磁共振成像实时监控肿瘤变化，为实现肿瘤靶向化疗及疗效追踪同步化的多功能给药系统提供新的思路和方法。
Fei Xiong, Caiyun Yan, Yuejian Chen, Jianxiang Chen, Bingya Yang, Yu Zhang, Huile Gao, Zichun Hua, Ning Gu*, Rubik-like magnetic nanoassemblies as an efficient drug multifunctional carrier for cancer theranostics. J. Control. Rel., 172(3): 993-1001, 2013.
Fig. 1. Schematic representing formulation and structure of Rubik like PTX-MNAs. Upon encapsulation in nanoassemblies, the hydrophobic PTX was inserted in the oleic acid cap of Fe3O4@OA NCs. The polymers were anchored on the surface of Rubik cube like nanoassemblies by the hydrophobic interaction between oleic acid cap of Fe3O4 NCs and oleic acid terminal of amphiphilic polymers.
