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杨芳


 

杨芳

Yang Fang(杨芳)

  教授/博导

Ph. D, Professor, Doctoral supervisor

State Key Laboratory of Bioelectronics

Jiangsu Key Laboratory for Biomaterials and Devices

School of Biological Science & Medical Engineering

SoutheastUniversity

Nanjing, Jiangsu, P. R. China 210096

Tel: 86-25-83272476-8009

Fax: 86-25-83272460

Email: yangfang2080@seu.edu.cn

 

Education Experience:

2006.3-2009.6  Biological Science & Medical Engineering, Southeast University, Ph.D Degree

2002.9-2004.6  Life College of Science and Engineering, ShaanXi University of Science & technology, Master Degree

2001.9-2002.7  Departments of Pharmaceutics, Shenyang Pharmaceutical University for pharmaceutics, Master Degree courses

1997.9-2001.7  Department of Food Science and Engineering, Northwest Institute of Light Industry, B.S Degree 

Research Experience:

2016.04-   School of Biological Science & Medical Engineering, Southeast University, Professor

2012.04-2016.04   School of Biological Science & Medical Engineering, Southeast University, Associate Professor

2013.12-2014.12   Department of Biomedical Engineering, University of Carlifornia, Davis, Visisting scholoar

2012.10-2012.12   Department of Chemistrey, The Univesity of Michigan, Visiting scholar

2009.09-2012.04   School of Biological Science & Medical Engineering, Southeast University, Lecturer 

Research Interestes:

  • Fabrication novel microbubbles for multimodality biomedical imaging 

  • Ultrasound imaging guided drug delivery

  • Novel ultrasound sensitive micro-, nano- delivery system

  • Ultrasonic theranostics 

Fundings:

  • National Natural Science Foundation of China(31000453,31370019, 81971750) 

  • National Key Basic Research Program of China (2013CB733804, 2018YFA0704103)

  • Author of National Excellent Doctoral Dissertation of PR China (201259)

  • Specialized Research Fund for the Doctoral Program of Higher Education of China (20100092120038)

  • National Natural Science Foundation of Jiangsu Province (BK20191266)

 Selected Publications: 

2023年

[1] Jian Tang, Yang Liu, Mingxi Li, Xiao Wang, Anning Du, Ning Gu, Fang Yang*. Sphingosine‐1‐phosphate receptor targeted PLGA nanobubbles for inflammatory vascular endothelial cell catching. Adv. Healthcare Mater. 2023, https://doi.org/10.1002/adhm.202301407.

[2] Weiling Miao†, Yang Liu†, Jian Tang, Tiandong Chen, Fang Yang *. A Moexitecan Magnetic Liposomal Strategy for Ferroptosis-Enhanced Chemotherapy. Pharmaceutics 2023, 15: 2012.

[3] Yang Liu, Lin Cui, Xiao Wang, Weiling Miao, Yongxu Ju, Tiandong Chen, Huiting Xu, Ning Gu*, Fang Yang*. In situ nitric oxide gas nanogenerator reprograms glioma immunosuppressive microenvironment. Advanced Science, 2023, 10 (18): 2300679.

[4] Mingxi Li, Dongwen Deng, Zhe Chen, Wentao Liu, Gutian Zhao, Yu Zhang, Fang Yang*, Zhonghua Ni*. Magnetic nanoparticle loaded biodegradable vascular stents for magnetic resonance imaging and long-term visualization. Journal of Materials Chemistry B, 2023, 11, 3669-3678.

[5] Yongxu Ju, Huaijing Li, Jing Li, Ning Gu*, Fang Yang*. Dual-parameter cell biosensor for real-time monitoring of effects of propionic acid on neurons. Biosensor & Bioelectronics, 2023, 229: 115227.

[6] Haoli Yu, Yuesong Wang, Yan Chen, Mengyuan Cui, Fang Yang*, Peng Wang*, Min Ji*. Transmissible H-aggregated NIR-II fluorophore to the tumor cell membrane for enhanced PTT and synergistic therapy of cancer. Nano Convergence, 2023, 10(1): 3.



2022年

[1]Mingxi Li, Xiao Cheng, Zhe Chen, Zhonghua Ni, Ning Gu, Fang Yang*. Platelet magnetic nanocarriers as MRI sensors to delineate vascular injury network and targeted pre-protection in ischemic stroke. SCIENCE CHINA Materials, 2022, doi.org/10.1007/s40843-022-2177-x. 

[2] Jing Li, Yao Zhang, Zhichao Lou, Mingxi Li, Lin Cui, Zhenrong Yang, Lijuan Zhang, Yu Zhang, Ning Gu*, Fang Yang*. Magnetic Nanobubble Mechanical Stress Induces the Piezo1-Ca2+-BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke. Small, 2022, 18(23): 2201123 (1-15). 

[3] Mingxi Li, Liang Wang, Dalin Tang, Gutian Zhao, Zhonghua Ni, Ning Gu*, Fang Yang*. Hemodynamic Mimic Shear Stress for Platelet Membrane Nanobubbles Preparation and Integrin αIIbβ3 Conformation Regulation. Nano Letters, 2022, 22(1): 271–279. 

[4] Li Yang, Bin Huang, Fang Yang*, Yan Li, Ning Gu*. Theoretical Study of the Effects of Nanoparticles on the Acoustic Performance of Microbubbles. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2022, 69(1): 54-61. 

[5] Yang Liu, Tiandong Chen, Ning Gu*, Fang Yang*. Recent progress in bioactive gas delivery for cancer immunotherapy. Progress in Biomedical Engineering, 2022, 4: 022001.

[6] Xin Liu, Yuxiang Sun, Bo Chen, Yan Li, Peng Zhu, Peng Wang, Sen Yan, Yao Li, Fang Yang*, Ning Gu*. Novel magnetic silk fibroin scaffolds with delayed degradation for potential long-distance vascular repair. Bioactive Materials, 2022, 7: 126-143.


2021年

[1] Yang Liu, Xiao Wang, Jing Li, Jian Tang, Bin Li, Yu Zhang, Ning Gu*, Fang Yang*. Sphingosine 1-Phosphate Liposomes for Targeted Nitric Oxide Delivery to Mediate Anticancer Effects against Brain Glioma Tumors. Advanced Materials, 2021, 33 (30): 2101701. 

[2] Jing Li, Zhenqiang Fen, Ning Gu*, Fang Yang*. Superparamagnetic iron oxide nanoparticles assembled magnetic nanobubbles and their application for neural stem cells labeling. Journal of Materials Science & Technology, 2021, 63: 124-132.

[3]Juan Jin, Mei Li, Jing Li, Bin Li, Lei Duan, Fang Yang*, Ning Gu*. Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration. ACS Applied Materials & Interfaces, 2021, 13: 43880-43891.


2020年

[1]Mingxi Li, Jing Li, Jinpeng Chen, Yang Liu, Xiao Cheng, Fang Yang*, Ning Gu*. Platelet Membrane Biomimetic Magnetic Nanocarriers for Targeted Delivery and in Situ Generation of Nitric Oxide in Early Ischemic Stroke. ACS Nano, 2020, 14: 2024-2035.

[2]Jiaxu Ding, Jing Li, Fang Yang*, Ning Gu*. A Multi-Channel System for Temperature Sensing of Neural Stem Cells in Adherent Culture. Anal. Chem. 2020, 92 (4): 3270-3275.

[3]Yue Zhou, Ning Gu*, Fang Yang*. In situ microbubble-assisted, ultrasound-controlled release of superparamagnetic iron oxide nanoparticles from gastro-retentive tablets. International Journal of Pharmaceutics, 2020,586: ‏ 11961.

[4] Siyu Wang, Xixi Guo, Weijun Xiu, Yang Liu, Lili Ren, Huaxin Xiao, Fang Yang, Yu Gao*, Chenjie Xu, Lianhui Wang*. Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles. Science Advances, 2020, 6(31): eaaz8204.

[5]Juan Jin, Fang Yang*, Bin Li, Dong Liu, Lihong Wu, Yan Li, Ning Gu*. Temperature-regulated self-assembly of lipids at free bubbles interface: a green and simple method to prepare micro/nano bubbles. Nano Research, 2020, 13(4): 999-1007.

[6] Li Yang, Bin Huang, Feng Chen, Juan Jin, Zhiguo Qin, Fang Yang*, Yan Li, Ning Gu*. Indocyanine Green Assembled Nanobubbles with Enhanced Fluorescence and Photostability. Langmuir, 2020, 36(43): 12983-12989.

[7]Zhiguo Qin, Bo Chen, Yu Mao, Chu Shi, Yan Li, Xiao Huang*, Fang Yang*, Ning Gu*. Achieving Ultrasmall Prussian Blue Nanoparticles as High-Performance Biomedical Agents with Multifunctions. ACS Appl. Mater. Interfaces 2020, 12 (51): 57382–57390. 

[8]Juan Jin, Ru Wang, Jian Tang, Li Yang, Zhenqiang Feng, Chunxiang Xu, Fang Yang*, Ning Gu*. Dynamic tracking of bulk nanobubbles from microbubbles shrinkage to collapse. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 589: 124430(1-9). 

[9]Lei Duan, Li Yang, Juan Jin, Fang Yang*, Dong Liu, Ke Hu, Qinxin Wang, Yuanbin Yue, Ning Gu*. Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications. Theranostics. 2020, 10(2): 462-483. 

[10]Sen Ye, Yang Liu, Yi Lu, Yuqin Ji, Lianlian Mei, Mingwen Yang, Xiaoxuan Gong, Qian Gu, Di Li, Fang Yang*, Chun-Jian Li*. Cyclic RGD functionalized liposomes targeted to activated platelets for thrombosis dual-mode magnetic resonance imaging. Journal of Materials Chemistry B, 2020, 8(3), 447-453.

[11] Xinxing Chu, Jian Tang, Zhanli Geng, Xingya Wang, Gengyang Huo, Limin Zhou, Jing Wang, Kaiwei Yuan, Xiaodong Yang, Jun Hu*, Fang Yang*, Xingfei Zhou*, Lijuan Zhang*. Mechanical Properties of Sub-microbubbles with Nanoparticle-decorated Polymer Shell. Langmuir, 2020,35(52): 17090-17095. 


 2019年

[1] Zhiguo Qin, Bo Chen, Xiao Huang, Yu Mao, Yan Li, Fang Yang*, Ning Gu*. Magnetic internal heating-induced high performance Prussian blue nanoparticle preparation and excellent catalytic activity. Dalton Transactions, 2019, 48(46): 17169-17173. 

[2] Yang Liu, Jing Li, Heming Chen, Yan Cai, Tianyu Sheng, Peng Wang, Zhiyong Li, Fang Yang*, Ning Gu*. Magnet-activatable nanoliposomes as intracellular bubble microreactors to enhance drug delivery efficacy and burst cancer cells. Nanoscale, 2019, 11 (40): 18854-18865.

[3] Juan Jin, Zhenqiang Feng, Fang Yang*, Ning Gu*. Bulk Nanobubbles Fabricated by Repeated Compression of Microbubbles. Langmuir, 2019, 35(12): 4238-4245. 

[4] Taotao Liu, Mingxi Li, Jian Tang, Jing Li, Yue Zhou, Yang Liu, Fang Yang*, Ning Gu*. An acoustic strategy for gold nanoparticles loading in platelets as biomimetic multifunctional carriers. Journal of Materials Chemistry B, 2019, 7: 2138-2144. (Back cover)

 

2018年

[1] Mingxi Li, Yang Liu, Jinpeng Chen, Taotao Liu, Zhuxiao Gu, Jianqiong Zhang, Xiaochun Gu, Gaojun Teng, Fang Yang*, Ning Gu*. Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics. Theranostics, 2018, 8(18): 4870-4883. (SCI, IF: 8.537)

[2] Dong Liu, Zuoheng Zhang, Zhiguo Qin, Jing Xing, Yang Liu, Juan Jin, Fang Yang*, Ning Gu*. Sinapultide-loaded lipid microbubbles and the stabilization effect of sinapultide on the shell of lipid. Journal of Materials Chemistry B, 2018, 6(9): 1335-1341.(SCI, IF: 4.543)

[3] Juan Jin#, Taotao Liu#, Mingxi Li, Chuxiao Yuan, Yang Liu, Jian Tang, Zhenqiang Feng, Yue Zhou, Fang Yang*, Ning Gu*. Rapid in situ biosynthesis of gold nanoparticles in living platelets for multimodal biomedical imaging. Colloids and Surfaces B: Biointerfaces, 2018, 163: 385-393. (SCI, IF: 3.887) 

2017年

[1] Yang Liu, Mingxi Li, Fang Yang*, Ning Gu*. Magnetic drug delivery systems. Science Materials-China, 2017, 60(6): 471-486. (SCI, IF=3.956)

[2] Tuantuan Wang, Chuxiao Yuan, Bingyang Dai, Yang Liu, Mingxi Li, Zhenqiang Feng, Qing Jiang, Zhihong Xu, Ningwei Zhao, Ning Gu*, Fang Yang*. Click chemistry-mediated rapid microbubble catching for acute thrombus ultrasound molecular imaging. ChemBioChem, 2017,18, 1364-1368. (SCI, IF=2.850)

[3] Yang Liu, Fang Yang*, Chuxiao Yuan, Mingxi Li, Tuantuan Wang, Bo Chen, Juan Jin, Peng Zhao, Jiayi Tong, Shouhua Luo, Ning Gu*. Magnetic Nanoliposomes as In Situ Microbubble Bombers for Multimodality Image-Guided Cancer Theranostics. ACS Nano, 2017, 11(2): 1509-1519 (SCI, IF=13.334)

[4] Dong Liu, Jing Xing, Fei Xiong, Fang Yang*, Ning Gu*. Preparation and in vivo safety evaluations of antileukemic homoharringtonine-loaded PEGylated liposomes. Drug Development and Industrial Pharmacy, 2017, 43(4): 652-660. http://dx.doi.org/10.1080/03639045.2016.1275670. (SCI, IF=2.429)

 

2016年

[1] Lei Duan#, Fang Yang#, Wen He, Lina Song, Fan Qiu, Ning Xu, Lu Xu, Yu Zhang, Zichun Hua*, Ning Gu*. A multi-gradient targeting drug delivery system based on RGD-L-TRAIL -Labeled magnetic microbubbles for cancer theranostics. Advanced Functional Materials, 2016, 26, 8313-8324.(Co-first author)

[2] Dong Liu, Fang Yang*, Fei Xiong, Ning Gu*. The smart drug delivery system and its clinical potential. Theranostics, 2016, 6(9): 1306-1323.

[3] Galina Shapiro, Andrew W. Wong, Maxim Bez, Fang Yang, Sarah Tam, Lisa Even, Dmitriy Sheyn, Shiran Ben-David, Wafa Tawackoli, Gadi Pelleda, Katherine W. Ferrara, Dan Gazit. Multiparameter evaluation of in vivo gene delivery using ultrasound-guided, microbubble-enhanced sonoporation. Journal of Controlled Release, 2016, 223: 157-164.

[4] Fang Yang*, Mingxi Li, Yang Liu, Tuantuan Wang, Zhenqiang Feng, Huating Cui, Ning Gu*, Glucose and magnetic-responsive approach toward in situ nitric oxide bubbles controlled generation for hyperglycemia theranostics, Journal of Controlled Release, 2016, 228: 87-95.

[5] Fangfang Shi, Fang Yang, Xiangfeng He, Ying Zhang, Songyan Wu, Miao Li, Yunxia Zhang, Wu Di, Jun Dou, Ning Gu. Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. J Drug Target, 2016, 24(1): 34-46.

~2015年

[1] Fang Yang, Xiaoxian Zhang*, Lina Song, Huating Cui, John N. Myers, Tingting Bai, Ying Zhou, Zhan Chen*, Ning Gu*. Controlled Drug Release and Hydrolysis Mechanism of Polymer–Magnetic Nanoparticle Composite. ACS Appl. Mater. Interfaces, 2015, 7 (18): 9410-9419.

[2] Kun Fang, Lina Song, Zhuxiao Gu, Fang Yang*, Yu Zhang, Ning Gu*, Magnetic field activated drug release system based on magnetic PLGA microspheres for chemo-thermal therapy, Colloids and Surfaces B: Biointerfaces 2015, 136, 712-720.

[3] Jilai Tian, Fang Yang*, Huating Cui, Ying Zhou, Xiaobo Ruan, Ning Gu*. A novel approach to making the gas-filled liposome real: based on the interaction of lipid with free nanobubbles within the solution. ACS Appl. Mater. Interfaces, 2015, 7 (48): 26579-26584.

[4] Lei Duan, Fang Yang, Lina Song, Kun Fang, Jilai Tian, Yijun Liang, Mingxi Li, Ning Xu, Zhongda Chen, Yu Zhang, Ning Gu*. Controlled assembly of magnetic nanoparticles on microbubbles for multimodal imaging. Soft Matter, 2015, 11, 5492-5500.

[5] Fangfang Shi, Fang Yang, Xiangfeng He, Ying Zhang, Songyan Wu, Miao Li, Yunxia Zhang, Wu Di, Jun Dou, Ning Gu. Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. J Drug Target, 2016, 24(1):34-46.

[6] Fang Yang, Mingxi Li, Huating Cui, Tuantuan Wang, Zhongwen Chen, Lina Song, Zhuxiao Gu, Yu Zhang, Ning Gu*. Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles. SCIENCE CHINA Materials, 2015, 58(6): 467-480.

[7] Kun Fang, Fang Yang, Qiying Zhang, Tianzhu Zhang, Ning Gu*. Fabrication of nonporous and porous cationic PLGA microspheres, Materials Letters, 2014, 117(15): 86-89.

[8] Fang Yang*, Qing Wang, Zhuxiao Gu, Kun Fang, Gerard Marriott, Ning Gu*. Silver nanoparticle-embedded micro-bubble as a dual-mode ultrasound and optical imaging probe. ACS Appl. Mater. Interfaces, 2013, 5 (18): 9217–9223.

[9] Fang Yang, Sunling Hu, Yu Zhang, Xiaowei Cai, Yan Huang, Feng Wang, Song Wen, Gaojun Teng, Ning Gu*. A Hydrogen Peroxide-Responsive O2 Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging. Adv. Mater. 2012, 24(38): 5205–5211.

[10] Xiaowei Cai, Fang Yang, Ning Gu*. Applications of Magnetic Microbubbles for Theranostics. Theranostics, 2012; 2(1):103-112.

[11] Wen He, Fang Yang, Yihang Wu, Song Wen, Ping Chen, Yu Zhang, Ning Gu*. Microbubbles with surface coated by superparamagnetic iron oxide nanoparticles. Materials Letters, 2012, 68(1): 64-67.

[12] Fang Yang, Miao Zhang, Wen He, Ping Chen, Xiaowei Cai, Li Yang, Ning Gu*, Junru Wu. Controlled Release of Fe3O4 Nanoparticles in Encapsulated Microbubbles to Tumor Cells via Sonoporation and Associated Cellular Bioeffects, Small 2011, 7(7), 902–910

[13] Fang Yang, Ping Chen, Wen He, Ning Gu*, Xizhi Zhang, Kun Fang, Yu Zhang, JianFei Sun, Jiayi Tong. Bubble Microreactors Triggered by an Alternating Magnetic Field as Diagnostic and Therapeutic Delivery Devices. Small, 2010, 6(12): 1300-1305.

[14] Fang Yang, Yixin Li, Zhongpin Chen, Yu Zhang, Junru Wu, Ning Gu*. Superparamagnetic Iron Oxide Nanoparticle-embedded Encapsulated Microbubbles as Dual Magnetic Resonance and Ultrasound Imaging Contrast Agents. Biomaterials, 2009, 30(23-24):3 882-3890.

[15] Fang Yang, Ning Gu*, Di Chen, Xiaoyu Xi, Dong Zhang, Yixin Li, Junru Wu. Experimental study on cell self-sealing during sonoporation. Journal of Controlled Release, 2008, 131(3): 205-210.