东南大学江苏省生物材料与器件重点实验室，生物与医学纳米技术研究组，副研究员
shengjingyi@hotmail.com
工作及教育经历
Ø 2020.09-至今 东南大学 生物科学与医学工程学院 副研究员
Ø 2016.11-2019.04 香港中文大学 医学院 内科与药物治疗系 博士后
Ø 2012.04-2016.10 墨尔本大学 医学院 细胞信号通路/免疫学 哲学博士
Ø 2005.08-2010.06 东南大学 公共卫生学院 预防医学专业 医学学士
研究方向
Ø 基于铁基纳米材料的心血管免疫调控：针对血管疾病的降脂及抗炎疫苗开发；血管早期炎症及动脉粥样硬化的免疫调控。
Ø 磁性纳米材料的免疫调控机制及应用：铁基纳米材料运用于免疫细胞的体内命运动态示踪；铁基纳米材料影响树突状细胞（DC）、巨噬细胞等免疫细胞的功能及调控机制研究。
科研项目
Ø 国家自然科学基金青年项目，32301189, 主持
(PCSK9/ApoB-100双靶向动脉粥样硬化磁性纳米脂质体疫苗的构建及应用)
Ø 江苏省自然科学基金青年项目, BK20220824，主持
(双靶向递送纳米脂质体肿瘤疫苗的制备及应用)
Ø 江苏省双创博士, JSSCBS20210107, 主持
(磁性纳米材料应用于树突状细胞（DC)疫苗的示踪研究)
Ø 科技部重点研发计划子课题，2021YFA1201403，参与
(新型磁性微纳器件及磁场遥控系统研发)
学术论文
(1) Jingyi Sheng#*, Yang Liu#, Ding He, Lingyuan Wu, Lan Liu, Guangxiang Si, Yan Shen, Fang Yang*, Ning Gu*, Magnetic delivery of antigen-loaded magnetic liposomes for active lymph node targeting and enhanced anti-tumour immunity, Advanced Healthcare Materials, 2023, 2301232. https://doi.org/10.1002/adhm.202301232
(2) Jingyi Sheng, Yuehuang Wu, He Ding, Kaizheng Feng, Yan Shen, Yu Zhang*, Ning Gu*, Multienzyme-like Nanozymes: Regulation, Rational Design, and Application, Advanced Materials, 2023, doi.org/10.1002/adma.202211210
(3) Chu Shi, Jingyi Sheng*, Guangxiang Si, Yan Li, Yan Shen, Ning Gu*, Spy chemistry enables stable protein immobilization on iron oxide nanoparticles with enhanced magnetic properties, Journal of Materials Science&Techonology, 2023,10(161),161-169.
(4) Dewen Ye, Mingxi Li, Kaizheng Feng,Yu Zhang, Jingyi Sheng*, Ning Gu*, Long-term fate tracking and quantitative analyzing of nanoparticles in stem cells with bright-field microscopy, Nano Today, 2022, 44: 101506-101506
(5) He Ding, Yuxin Zhang,Yu Mao, Yan Li, Yan Shen, Jingyi Sheng*, Ning Gu*, Modulation of macrophage polarization by iron-based nanoparticles, Medical Review, 2023, doi.org/10.1515/mr-2023-0002
(6) Jingyi Sheng#, Li Wang#, Patrick Ming-Kuen Tang#, Hong-Lian Wang, Jian-Chun Li, Bi-Hua Xu, Vivian Weiwen Xue, Rui-Zhi Tan, Nana Jin, Ting-Fung Chan, Xiao-Ru Huang, Ronald CW Ma, Hui-Yao Lan*, Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression, Theranostics, 2021, 11(6): 2845-2859.
(7) Jingyi Sheng, Chu Shi and Ning Gu*, Clinical trials of MRI-based immune cell imaging: challenges and perspectives, Science Bulletin, 2021, 66(4):303-306
(8) Jian Zhang#, Jingyi Sheng#, Liwei Dong, Yinli Xu, Liming Yu, Yu Liu, Xiaoru Huang, Song Wan, Hui-Yao Lan*, Huishan Wang*, Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causesmyocardial dysfunction and heart failure, Cardiovascular Research, 2019,115(11):1617-1628
(9) Honglian Wang#, Jingyi Sheng#, Huijun He, Xiaocui Chen, Jinhong Li, Ruizhu Tan, Li Wang, Hui-Yao Lan*, A simple and highly purified method for isolation of glomeruli from the mouse kidney, American Journal of Physiology Renal Physiology, 2019, 317: F1217-F1223
